📄 Category

cancer biology

298 papers

Cancer biology explores the complex ways cells grow out of control, investigating the genetic mutations and environmental factors that drive tumor formation. This field seeks to understand how healthy cells transform into malignant ones and how these rogue cells spread throughout the body. By decoding these fundamental mechanisms, researchers aim to develop more effective treatments that target the disease at its source while sparing healthy tissue.

At Gist.Science, we process every new preprint published in this category directly from bioRxiv to ensure you stay ahead of the curve. Our team provides both accessible plain-language overviews and detailed technical summaries for each study, bridging the gap between raw research data and practical understanding. Whether you are a specialist or a curious reader, our goal is to make these critical findings clear and actionable.

Below are the latest papers in cancer biology, offering fresh insights into the ongoing fight against this disease.

📄 cancer biology

Longitudinal single-cell and spatial transcriptomics reveals intratumor heterogeneity, therapeutic response, and comparative value of canine marginal zone lymphoma

This study utilizes longitudinal single-cell and spatial transcriptomics to characterize intratumoral heterogeneity and therapeutic responses in a canine marginal zone lymphoma case, revealing that while oncolytic VSV virotherapy successfully targeted B cells, the resulting cytotoxic immune response was primarily driven by T cells, thereby highlighting the need for improved subtyping and multidimensional treatment strategies.

Walker, G. E., Macchietto, M., Reid, K., Burt, L. E., Winter, A., Pracht, S., Buettner, M., Penza, V., Yung, C., Dicovit (…)2026-09-14
📄 cancer biology

Patient-derived IgG Amplifies Fcγ Receptor-Dependent Colonic Inflammation During Immune Checkpoint Blockade

This study demonstrates that patient-derived IgG antibodies, characterized by a specific autoantibody signature, amplify immune checkpoint inhibitor-induced colonic inflammation in a humanized Fcγ receptor-dependent manner, revealing pretreatment humoral immunity as a key determinant of severe immune-related colitis susceptibility.

Voloshyna, I., Patskovsky, Y., Sandigursky, S., Sreenivasaiah, C., Bayrakta, E. C., Tardio, E., Lopez, A. V., Idga, S. (…)2026-09-11
📄 cancer biology

Characterisation of prostate cancer sialome re-engineering via CMAH transfection reveals a bystander effect that propagates Neu5Gc presentation to neighbouring cells

This study demonstrates that re-engineering prostate cancer cells to express rat CMAH induces Neu5Gc presentation on cell-surface glycans and reveals a bystander effect where Neu5Gc is transferred to neighboring cells, potentially propagating immune suppression within the tumor microenvironment.

Uno, Y., Noble, A., Hutton, E., Signoret, N., Fascione, M.2026-09-11
📄 cancer biology

Furan fatty acid supplementation protects against muscle atrophy during cancer cachexia

This study demonstrates that supplementation with the naturally occurring lipid FuFA-F2 effectively prevents tumor-induced skeletal muscle atrophy and preserves muscle function in a cancer cachexia mouse model by attenuating inflammatory, catabolic, and fibrotic pathways without affecting tumor growth.

Deglos, A., Falconi, J., Geminard, C., Bertrand-Gaday, C., Bonafos, B., Bauer, V., Heron-Milhavet, L., Durand, E., Delob (…)2026-09-10
📄 cancer biology

A combined program of induced stemness and differentiation in response to interferon gamma drives acute myeloid leukaemia growth

This study reveals that interferon gamma drives acute myeloid leukemia growth by triggering a paradoxical intraclonal fate bifurcation where leukemic stem cells deepen their quiescent stemness while progenitor cells undergo rapid but transient differentiation, ultimately enabling long-term disease regeneration despite inflammatory challenges.

Pospori, C., Donada, A., Boutzen, H., Grey, W., Rabas, N., Kassara, N., Sun, W., Birch, F., Georgiou, C., Gibson, S., Yo (…)2026-09-10
📄 cancer biology

Myeloid Lectin Profiling Identifies SYK as a Targetable Signaling Node for Remodeling Immunosuppressive Tumor-Associated Macrophages in Breast Cancer

This study identifies a specific panel of myeloid lectins associated with immunosuppressive tumor-associated macrophages in breast cancer and demonstrates that pharmacologically targeting their shared SYK signaling node effectively remodels these macrophages to reduce immunosuppression.

Trindade, G., Domenici, G., Pinto, M., Correia, V., Batalha, S., Duarte, N., Palma, A. S., Isidro, I. A., Brito, C.2026-09-08
📄 cancer biology

CAMOR and specific oncogene-driven lncRNAs mediate carcinogenic functions downstream of MYC, mutant KRAS, and mutant TP53

This study identifies and characterizes specific long non-coding RNAs, including the pan-cancer regulator CAMOR, that are driven by major oncogenic mutations (MYC, KRAS, TP53) and functionally promote carcinogenesis across colorectal, lung, and pancreatic cancers, thereby offering new potential diagnostic and therapeutic targets.

Grzes, M., Jaiswar, A., Kazmierczak, W., Olesinski, T., Nowak-Niezgoda, M., Walerych, D.2026-09-08
📄 cancer biology

Cross-species analysis links cell-cell communication rewiring to NOTCH2 during serous endometrial carcinogenesis

This study utilizes cross-species analysis of a mouse model and human tissues to demonstrate that cell-cell communication rewiring, specifically driven by NOTCH2 overexpression, is a conserved early event in serous endometrial carcinogenesis that promotes tumor progression and correlates with poor patient survival.

Pirtz, M. G., Flesken-Nikitin, A., Ralston, C. Q., Phuong, D. J., Wang, N., Chu, T., Chen, S., Zheng, Y., Schmoeckel, E. (…)2026-09-03
📄 cancer biology

Patient-Derived Glioma Models Preserve Tumor Heterogeneity and Identify Stearoyl-CoA Desaturase1 (SCD1) as a Candidate Biomarker for Precision Immunotherapy

This study demonstrates that patient-derived brain tumor models faithfully recapitulate the molecular and histological heterogeneity of primary tumors, enabling the identification of Stearoyl-CoA Desaturase1 (SCD1) as a promising biomarker and therapeutic target for precision immunotherapy in glioma.

Gutova, M., Ma, E., Natri, H. M., Sepulveda, S., Mankame, S., Uyematsu, S., Hibbard, J., Aftabizadeh, M., Ma, X., Starr (…)2026-09-03
📄 cancer biology

Multi-hit STAG2 mutations define a high-risk subset of MDS and reveal convergent evolutionary targeting of cohesin

This study identifies that multiple STAG2 mutations in myeloid neoplasms, particularly myelodysplastic syndromes (MDS), arise through convergent evolutionary targeting rather than stepwise allelic inactivation, defining a distinct high-risk subset characterized by increased multilineage dysplasia and inferior overall survival.

Udoh, E.-o. B., Chen, Y., D'Addona, M., Stewart, E., Deng, R., de Almeida Sartori, F., Unlu, S., Brady, Z., Zhu, R., Che (…)2026-09-03